Citation
Yk. Kim et al., Cytotoxic triterpenes from stem bark of Physocarpus intermedius, PLANTA MED, 66(5), 2000, pp. 485-486
Citations number
9
Categorie Soggetti
Pharmacology & Toxicology
Journal title
PLANTA MEDICA
ISSN journal
00320943
→ ACNP
Volume
66
Issue
5
Year of publication
2000
Pages
485 - 486
Database
ISI
SICI code
0032-0943(200006)66:5<485:CTFSBO>2.0.ZU;2-2
Abstract
Seven triterpenes (1-7), i.e., betulinic acid 1, ursolic acid 2, oleanolic
acid 3, 3-O-caffeoyloleanolic acid 4, euscaphic acid 5, 2 alpha-hydroxyurso
lic acid 6 and maslinic acid 7 were isolated from the stem bark extract of
P. intermedius as active principles responsible for the cytotoxicity agains
t five cultured human tumor cell lines, i.e., A549 (non small cell lung), S
K-OV-3 (ovary). SK-MEL-2 (melanoma), XF498 (central nerve system) and HCT-1
5 (colon), in vitro.