Js. Ferguson et Dc. Hendershot, The impact of toxicity dose-response relationships on quantitative risk analysis results, PROC SAF PR, 19(2), 2000, pp. 91-97
The toxicity dose-response relationship is a critical data requirement for
a quantitative risk analysis of a chemical processing facility. This paper
will review:
The use of toxicity dose-response relationships in a quantitative risk anal
ysis
The development of dose-response relationships for use in a quantitative ri
sk analysis from toxicity data
Examples of variation in published dose-response relationships for some com
mon chemicals
The impact of differences in dose-response relationships on the results of
a quantitative risk analysis
Finally, we propose the development of a standard protocol for development
of toxicity dose-response relationships for use in quantitative risk analys
is, with emphasis on the benefits to the chemical industry of a standardize
d methodology.