Synthesis of regiospecifically labeled physiologically active compounds with a high molar radioactivity using gaseous tritium

Authors
Shevchenko, VP Nagaev, IY Myasoedov, NF Kamernitskii, AV Levina, IS Kulikova, LE
Citation
Vp. Shevchenko et al., Synthesis of regiospecifically labeled physiologically active compounds with a high molar radioactivity using gaseous tritium, RADIOCHEMIS, 42(2), 2000, pp. 191-195
Citations number
6
Categorie Soggetti
Inorganic & Nuclear Chemistry
Journal title
RADIOCHEMISTRY
ISSN journal
10663622 → ACNP
Volume
42
Issue
2
Year of publication
2000
Pages
191 - 195
Database
ISI
SICI code
1066-3622(200003/04)42:2<191:SORLPA>2.0.ZU;2-Y
Abstract
Conditions of synthesis of tritium-labeled 16 alpha,17 alpha-cyclopentanopr ogesterone and isobutyric and palmitic acids with a high molar radioactivit y were examined. The degree of labeling was studied as influenced by the re action rime and temperature. Isotope exchange, as compared to hydrogenation , ensures several times higher molar radioactivity of the resulting organic acids.