Pq. Huang et al., An alternative stereoselective synthesis of protected trans-5-alkyl-4-hydroxy-2-pyrrolidinones, SYN COMMUN, 30(13), 2000, pp. 2259-2268
A flexible approach to protected trans-5-alkyl-4-hydroxy-2-pyrrolidinones w
as described. The key step involved the alpha-amidoalkylation of benzenesul
fone derived from (S)-malic acid, with organozinc reagents generated in sit
u from Grignard reagents and anhydrous ZnCl2. OEt2.