Ja. Squella et al., ELECTOREDUCTION OF 4-(NITROPHENYL) SUBSTITUTED 1,4-DIHYDROPYRIDINES ON THE MERCURY-ELECTRODE IN APROTIC MEDIUM, Electrochimica acta, 42(15), 1997, pp. 2305-2312
Electrochemical studies on 4-(nitrophenyl) substituted 1,4-dihydropyri
dines of pharmacological importance have allowed us to generate the on
e-electron reduction product, the nitro radical anion, ArNO2.-, in apr
otic media. Cyclic voltammetric technique have been employed to study
the tendency of ArNO2.- to undergo further chemical reaction. Second o
rder kinetics for the decay of ArNO2.- were established for all the 1,
4-dihydropyridines examined. The 1,4-dihydropyridine derivatives that
have the nitro group in the orto position in the ring shows a trend to
give less stable radicals when comparing with meta substitution. The
cyclic voltammograms of the couple ArNO2/ArNO2.- has also been examine
d in the presence and absence of glutathione concluding that it does n
ot exist interaction among glutathione and the nitro radical anions in
aprotic media. (C) 1997 Elsevier Science Ltd.