Highly diastereoselective alkylation of a pyroglutamate derivative with anelectrophile obtained from indole. synthesis of a potential intermediate for the preparation of the natural sweetener (-)-monatin

Authors
Oliveira, DDJ Coelho, F
Citation
Ddj. Oliveira et F. Coelho, Highly diastereoselective alkylation of a pyroglutamate derivative with anelectrophile obtained from indole. synthesis of a potential intermediate for the preparation of the natural sweetener (-)-monatin, SYN COMMUN, 30(12), 2000, pp. 2143-2159
Citations number
21
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
SYNTHETIC COMMUNICATIONS
ISSN journal
00397911 → ACNP
Volume
30
Issue
12
Year of publication
2000
Pages
2143 - 2159
Database
ISI
SICI code
0039-7911(2000)30:12<2143:HDAOAP>2.0.ZU;2-W
Abstract
The synthesis of a potential intermediate for the preparation of the very i ntensive sweetening agent (-)-Monatin is described. The synthesis is based on a highly diastereoselective alkylation reaction of a pyroglutamate deriv ative with an electrophile obtained from indole.