Citation
P. Li et Jc. Xu, New and highly efficient immonium type peptide coupling reagents: Synthesis, mechanism and application, TETRAHEDRON, 56(26), 2000, pp. 4437-4445
Citations number
25
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020
→ ACNP
Volume
56
Issue
26
Year of publication
2000
Pages
4437 - 4445
Database
ISI
SICI code
0040-4020(20000623)56:26<4437:NAHEIT>2.0.ZU;2-G
Abstract
A series of novel immonium type coupling reagents BOMI, BDMP, BPMP, DOMP, S
OMP, FOMP and AOMP were designed and synthesized. It was shown that most of
these reagents were more efficient in peptide synthesis than conventional
methods due to the advantages of high reactivity, low racemization and good
yields. The reaction mechanism was proposed and studied by H-1 NMR, IR, UV
and HPLC. (C) 2000 Elsevier Science Ltd. All rights reserved.