Pm. Fresneda et al., Synthetic studies towards the 2-aminopyrimidine alkaloids variolins and meridianins from marine origin, TETRAHEDR L, 41(24), 2000, pp. 4777-4780
A nine-step synthesis of 9-amino-4-methoxypyrido[3',2',4, 5]pyrrolo[1,2-c]p
yrimidine, a tricyclic ring system present in the marine alkaloids variolin
s is described. The natural marine products meridianins C-E have been synth
esized for the first time starting from N-protected 3-acylindoles, (C) 2000
Elsevier Science Ltd. All rights reserved.