Solid phase synthesis of glutamic acid derivatives via nucleophilic ring opening of N-Boc pyroglutamate with heteronucleophiles

Authors
de Blas, J Dominguez, E Ezquerra, J
Citation
J. De Blas et al., Solid phase synthesis of glutamic acid derivatives via nucleophilic ring opening of N-Boc pyroglutamate with heteronucleophiles, TETRAHEDR L, 41(23), 2000, pp. 4567-4571
Citations number
12
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
23
Year of publication
2000
Pages
4567 - 4571
Database
ISI
SICI code
0040-4039(20000612)41:23<4567:SPSOGA>2.0.ZU;2-K
Abstract
A solid phase method for the synthesis of glutamic acid derivatives based o n the chemoselective ring opening of N-Boc pyroglutamic-Wang resin by heter onucleophiles is described. It allows the preparation of a large number of amides and esters of glutamic acid in a simple procedure with moderate to g ood yields and excellent purity. (C) 2000 Elsevier Science Ltd. All rights reserved.