Enantioselective synthesis of 1,1,1-trifluoroalkan-2-ols by ruthenium-catalyzed hydrogenation

Authors
Kuroki, Y Asada, D Sakamaki, Y Iseki, K
Citation
Y. Kuroki et al., Enantioselective synthesis of 1,1,1-trifluoroalkan-2-ols by ruthenium-catalyzed hydrogenation, TETRAHEDR L, 41(23), 2000, pp. 4603-4607
Citations number
33
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
23
Year of publication
2000
Pages
4603 - 4607
Database
ISI
SICI code
0040-4039(20000612)41:23<4603:ESO1BR>2.0.ZU;2-#
Abstract
The highly enantioselective synthesis of 1,1,1-trifluoroalkan-2-ols has bee n achieved by hydrogenating 1,1,1 -trifluoroalkan-2-one enol acetates in th e presence of chiral ruthenium catalysts. An enol acetate, 2-acetoxy-3,3,3- trifluoro-1-(phenylthio)propene, can be successfully transformed into enant iomerically pure trifluorolactic acid. (C) 2000 Elsevier Science Ltd. All r ights reserved.