Total synthesis of a marine imidazole alkaloid, clathridine A

Authors
Ohta, S Tsuno, N Maeda, K Nakamura, S Taguchi, N Yamashita, M Kawasaki, I
Citation
S. Ohta et al., Total synthesis of a marine imidazole alkaloid, clathridine A, TETRAHEDR L, 41(23), 2000, pp. 4623-4627
Citations number
9
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
23
Year of publication
2000
Pages
4623 - 4627
Database
ISI
SICI code
0040-4039(20000612)41:23<4623:TSOAMI>2.0.ZU;2-4
Abstract
The first total synthesis of clathridine A (8), a marine imidazole alkaloid , was achieved by using a novel regioselective condensation as a key step, in which preclathridine A (2) was treated with 1-methylparabanic acid (11) in the presence of a silylating agent. (C) 2000 Elsevier Science Ltd. All r ights reserved.