Production of nitroxyl (HNO) at biologically relevant temperatures from the retro-Diels-Alder reaction of N-hydroxyurea-derived acyl nitroso-9,10-dimethylanthracene cycloadducts

Authors
Xu, YP Alavanja, MM Johnson, VL Yasaki, G King, SB
Citation
Yp. Xu et al., Production of nitroxyl (HNO) at biologically relevant temperatures from the retro-Diels-Alder reaction of N-hydroxyurea-derived acyl nitroso-9,10-dimethylanthracene cycloadducts, TETRAHEDR L, 41(22), 2000, pp. 4265-4269
Citations number
18
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
22
Year of publication
2000
Pages
4265 - 4269
Database
ISI
SICI code
0040-4039(20000608)41:22<4265:PON(AB>2.0.ZU;2-Q
Abstract
Retro Diels-Alder reaction of N-hydroxyurea-derived acyl nitroso compound-9 ,10-dimethylanthracene cycloadducts produce acyl nitroso compounds that rea ct with nucleophiles to form nitrous oxide, which indicates the intermediac y of nitroxyl. These results identify these molecules as a new group of nit roxyl delivery agents. (C) 2000 Elsevier Science Ltd. All rights reserved.