Design and synthesis of a novel photoaffinity taxoid as a potential probe for the study of paclitaxel-microtubules interactions

Authors
Lin, SN Fang, K Hashimoto, M Nakanishi, K Ojima, I
Citation
Sn. Lin et al., Design and synthesis of a novel photoaffinity taxoid as a potential probe for the study of paclitaxel-microtubules interactions, TETRAHEDR L, 41(22), 2000, pp. 4287-4290
Citations number
20
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
22
Year of publication
2000
Pages
4287 - 4290
Database
ISI
SICI code
0040-4039(20000608)41:22<4287:DASOAN>2.0.ZU;2-U
Abstract
A novel and non-radioactive bifunctional photoaffinity probe (BPP) for the study of paclitaxel-micro-tubules interactions is designed and synthesized. This new BPP-taxoid bears a 3-nitro-5-trifluoromethyl-diazirinyl-phenoxyac etyl group at C-3'N for photoaffinity/photocleavage and a biotin subunit at C-7 for affinity chromatography. (C) 2000 Elsevier Science Ltd. All rights reserved.