Selective monolithiation of 2,5-dibromopyridine with butyllithium

Authors
Wang, X Rabbat, P O'Shea, P Tillyer, R Grabowski, EJJ Reider, PJ
Citation
X. Wang et al., Selective monolithiation of 2,5-dibromopyridine with butyllithium, TETRAHEDR L, 41(22), 2000, pp. 4335-4338
Citations number
9
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
22
Year of publication
2000
Pages
4335 - 4338
Database
ISI
SICI code
0040-4039(20000608)41:22<4335:SMO2WB>2.0.ZU;2-5
Abstract
Selective monolithiation of 2,5-dibromopyridine at either the 2-position or the 5-position is reported. Solvent and concentration strongly influence t he selectivity. Coordinating solvents and higher concentration favor the 5- position while non-coordinating solvents and lower concentration favor the 2-position. (C) 2000 Published by Elsevier Science Ltd.