A highly advanced enantiomerically pure C(1)-C(18) precursor of the larger
fragment of the macro-diolide pamamycin-607 has been synthesized. The stere
otriad C(7)-C(9) between the two heterocyclic rings of the target was gener
ated using a diastereoselective hydroboration controlled by minimization of
allylic 1,3-strain. (C) 2000 Elsevier Science Ltd. All rights reserved.