A sultone approach to the C(1)-C(18) moiety of pamamycin-607

Authors
Bernsmann, H Frohlich, R Metz, P
Citation
H. Bernsmann et al., A sultone approach to the C(1)-C(18) moiety of pamamycin-607, TETRAHEDR L, 41(22), 2000, pp. 4347-4351
Citations number
29
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
22
Year of publication
2000
Pages
4347 - 4351
Database
ISI
SICI code
0040-4039(20000608)41:22<4347:ASATTC>2.0.ZU;2-7
Abstract
A highly advanced enantiomerically pure C(1)-C(18) precursor of the larger fragment of the macro-diolide pamamycin-607 has been synthesized. The stere otriad C(7)-C(9) between the two heterocyclic rings of the target was gener ated using a diastereoselective hydroboration controlled by minimization of allylic 1,3-strain. (C) 2000 Elsevier Science Ltd. All rights reserved.