Isolation of erinacine P, a new parental metabolite of cyathane-xylosides,from Hericium erinaceum and its biomimetic conversion into erinacines A and B
H. Kenmoku et al., Isolation of erinacine P, a new parental metabolite of cyathane-xylosides,from Hericium erinaceum and its biomimetic conversion into erinacines A and B, TETRAHEDR L, 41(22), 2000, pp. 4389-4393
A new cyathane-xyloside, erinacine P, was isolated from mycelia of basidiom
ycetous Hericium erinaceum YB4-6237 in a shaken culture. Since its aglycon
closely resembles typical cyathane diterpenoids such as cyathins and cyatha
triols in its substitution pattern, this glycoside seems to be an important
metabolite in the biosynthesis of erinacines and striatins. In fact, accor
ding to our biogenesis studies, erinacine P can be successfully converted c
hemically into erinacine B and, further, to erinacine A under mild conditio
ns. (C) 2000 Elsevier Science Ltd. All rights reserved.