Synthesis of (R)-4,4,4-trifluoro-2-mercaptobutyric acid

Authors
Schedel, H Quaedflieg, PJLM Broxterman, QB Bisson, W Duchateau, ALL Maes, ICH Herzschuh, R Burger, K
Citation
H. Schedel et al., Synthesis of (R)-4,4,4-trifluoro-2-mercaptobutyric acid, TETRAHEDR-A, 11(10), 2000, pp. 2125-2131
Citations number
46
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON-ASYMMETRY
ISSN journal
09574166 → ACNP
Volume
11
Issue
10
Year of publication
2000
Pages
2125 - 2131
Database
ISI
SICI code
0957-4166(20000602)11:10<2125:SO(A>2.0.ZU;2-H
Abstract
Syntheses of (R)-4,4,4-trifluoro-2-mercaptobutyric acid from (S)-malic acid via a Mitsunobu reaction and from (rac)-thiomalic acid on enzymatic resolu tion, using Pseudomonas cepacia (Amano lipase PS), are described. A new met hod for direct determination of ees for (R)- and (S)-4,4,4-trifluoro-2-merc aptobutyric acid derivatives by HPLC on a polysaccharide phase is disclosed . (C) 2000 Elsevier Science Ltd. All rights reserved.