DEVELOPMENT OF AN ANTI-HIV GENOTHERAPY BA SED ON THE ANTIVIRAL PROPERTIES OF BETA-INTERFERON

Authors
DEMAEYER E VIEILLARD V CREMER I ROUSSEAU V JACOMET C DEBRE P ROZENBAUM W AUTRAN B LAURET E
Citation
E. Demaeyer et al., DEVELOPMENT OF AN ANTI-HIV GENOTHERAPY BA SED ON THE ANTIVIRAL PROPERTIES OF BETA-INTERFERON, Transfusion clinique et biologique, 4(3), 1997, pp. 281-286
Citations number
13
Categorie Soggetti
Hematology,Immunology
Journal title
Transfusion clinique et biologique → ACNP
ISSN journal
12467820
Volume
4
Issue
3
Year of publication
1997
Pages
281 - 286
Database
ISI
SICI code
1246-7820(1997)4:3<281:DOAAGB>2.0.ZU;2-G
Abstract
The aim of our work is to explore the use of IFN-beta for gene therapy in the HIV-infection. Transduction of various HIV target cells with a retroviral vector that carries tl-re Hu-IFN-beta coding sequence unde r constitutive low expression control, confers resistance to HIV witho ut affecting cell replication or function. After transduction, lymphoc ytes from HIV-infected patients develop resistance to the endogenous v irus, provided the cells are derived from individuals with a CD4 cell count higher than 200 per mm(3).