Dominant role of the C-terminal domain in the binding of apolipoprotein(a)to the protein core of proteoglycans and other members of the vascular matrix

Authors
Scanu, AM Edelstein, C Klezovitch, O
Citation
Am. Scanu et al., Dominant role of the C-terminal domain in the binding of apolipoprotein(a)to the protein core of proteoglycans and other members of the vascular matrix, TREND CARD, 9(7), 1999, pp. 196-200
Citations number
37
Categorie Soggetti
Cardiovascular & Hematology Research
Journal title
TRENDS IN CARDIOVASCULAR MEDICINE
ISSN journal
10501738 → ACNP
Volume
9
Issue
7
Year of publication
1999
Pages
196 - 200
Database
ISI
SICI code
1050-1738(199910)9:7<196:DROTCD>2.0.ZU;2-D
Abstract
The C-terminal domain of apolipoprotein(a) binds in vitro to the protein co re of proteoglycans as well as fibrinogen and fibronectin, suggesting that this domain plays a role in anchoring lipoprotein(a) or free apolipoprotein (a) to the vascular subendothelial matrix. (Trends Cardiovasc Med 1999;9:19 6-200). (C) 1999, Elsevier Science Inc.