Phosphinooxazolines - A new class of versatile, modular P,N-ligands for asymmetric catalysis

Authors
Helmchen, G Pfaltz, A
Citation
G. Helmchen et A. Pfaltz, Phosphinooxazolines - A new class of versatile, modular P,N-ligands for asymmetric catalysis, ACC CHEM RE, 33(6), 2000, pp. 336-345
Citations number
62
Categorie Soggetti
Chemistry & Analysis",Chemistry
Journal title
ACCOUNTS OF CHEMICAL RESEARCH
ISSN journal
00014842 → ACNP
Volume
33
Issue
6
Year of publication
2000
Pages
336 - 345
Database
ISI
SICI code
0001-4842(200006)33:6<336:P-ANCO>2.0.ZU;2-9
Abstract
Chiral phosphinooxazolines (PHOX ligands), which coordinate to a metal cent er with a N- and a P-atom, allow effective enantio-control in a variety of metal-catalyzed reactions. They are readily synthesized, and because of the ir modular structure, the steric and electronic properties can be tailored for a specific application by variation of the oxazoline ring, the backbone , and the phosphine moiety.