De. Frantz et al., The discovery of novel reactivity in the development of C-C bond-forming reactions: In situ generation of zinc acetylides with Zn-II/R3N, ACC CHEM RE, 33(6), 2000, pp. 373-381
There have been great strides in expanding the scope, application, and vers
atility of known reaction types (i.e., Mukaiyama aldol). It is interesting
to speculate that limitations in the number of such known basic reaction ty
pes constitute the greatest barrier in the development of practical process
es. The catalytic generation of transition-metal metalloenolates and alkyni
lides under conditions compatible with electrophilic reaction partners prov
ides fresh avenues for the development of new efficient asymmetric processe
s leading to C-C bond formation.