Characterization of difatty acid diamminoplatinum and effects of magnetic field on their anticancer activity

This paper presents the results of the research using FT-IR NMR and element ary analysis to investigate the physics-chemical properties and structures of difatty acid diamminoplatinum. The results of elementary analysis show t hat the theoretical value tallies with the experimental one. The FT-IR spec troscopy shows the presence of the functional groups that are supposed to b e present in the structure. In the experiment, human hematopoietic cell K-5 62, human melanoma cell LiBr, and human cancer cell of the liver 7721 were used as the external model. The influence of the magnetic field on the micr ocosmic structure of human tumour cell membrane was studied by the techniqu e of scanning electron microscope (SEM). The effecting of difatty acid diam minoplatinum on cell damaged was determined by means of MTT test. The exper imental results show that the cell damaging effect has a direct bearing on the concentration with the length of hydrocarbon chain. The influence of ma gnetic field on the interaction between difatty acid diamminoplatinum and h uman tumor cells show that the cell damaging effects are closely related wi th the magnetic field intensity.