Incremental reduction of serum total cholesterol and low-density lipoprotein cholesterol with the addition of plant stanol ester-containing spread tostatin therapy
Sn. Blair et al., Incremental reduction of serum total cholesterol and low-density lipoprotein cholesterol with the addition of plant stanol ester-containing spread tostatin therapy, AM J CARD, 86(1), 2000, pp. 46-52
Citations number
21
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
This study compares the effect of plant stanol ester spread with a placebo
spread on cholesterol in patients taking statin therapy, but who still had
elevated low-density lipoprotein (LDL) cholesterol. This was a randomized,
double-blind, placebo-controlled clinical trial, with 67 women and 100 men
with LDL cholesterol greater than or equal to 130 mg/dl and triglycerides l
ess than or equal to 350 mg/dl who had been taking a stable dose of a stati
n drug for at least 90 days before the start of the study. For 8 weeks, par
ticipants consumed 3 servings/day of the plant stanol ester spread that pro
vided 5.1 g/day of plant stanol ester or a placebo. The addition of plant s
tanol ester spread significantly reduced total cholesterol and LDL choleste
rol at 2, 4, and 8 weeks when compared with placebo spread. Plant stanol es
ter spread reduced total cholesterol at 8 weeks by 12% compared with a plac
ebo reduction of 5% (-7% difference; p <0.0001). Plant stanol ester spread
reduced LDL cholesterol at 8 weeks by 17% compared with a 7% reduction in t
he placebo group (-10% difference, p <0.0001). The absolute reduction in LD
L cholesterol at 8 weeks was 24 and 10 mg/dl in the stanol ester and placeb
o groups, respectively. The plant stanol ester spread group also had greate
r reductions in both serum total cholesterol and LDL cholesterol than the p
lacebo group at 2 and 4 weeks (p <0.001 for all comparisons). Both spreads
were well tolerated by study participants, and no significant adverse event
s were noted. Consumption of spread that provided 5.1 g/day of plant stanol
esters effectively reduced elevated total and LDL cholesterol levels in pa
rticipants on a stable regimen of a statin. (C) 2000 by Excerpta Medico, In
c.