Postoperative atrial fibrillation (AF) is a frequent adverse event after co
ronary artery bypass grafting (CABG) and may negatively affect the early cl
inical outcome. We sought to investigate the risk factors, prevalence, and
prognostic implications of postoperative AF in patients submitted to CABG w
ithout cardiopulmonary bypass (off-pump). The study population comprised 96
9 patients, 645 men (67%) and 324 women (33%) who had off-pump CABG at the
Washington Hospital Center from January 1987 to May 1999. Preoperative AF p
atients were excluded (n = 15). Two hundred six patients (age 69 +/- 10 yea
rs, 137 men [66%]) developed AF, whereas 763 patients (age 61 +/- 12 years,
508 men [67%]) did not. predictors of AF included age >75 years (odds rati
o [OR] 3.0, 95% confidence interval [CI] 1.9 to 4.5; p <0.001), history of
stroke (OR 2.1, CI 1.2 to 3.7; p 0.007), postoperative pleural effusion req
uiring thoracentesis (OR 3.2, CI 1.0 to 9.4; p 0.03), and postoperative pul
monary edema (OR 5.1, CI 1.2 to 21; p = 0.02). Minimally invasive direct CA
BG was associated with a lower incidence of AF (OR 0.4, CI 0.3 to 0.7; p <0
.001). AF was associated with a prolonged postoperative hospital stay (9 +/
- 6 days AF vs 6 +/- 5 days no AF, p <0.001). In-hospital mortality was sig
nificantly higher in AF patients (3% AF vs 1% no AF, p = 0.009). patients w
ith persistent AF had a higher postoperative in-hospital stroke rate than p
atients without persistent AF (9% vs 0.6%, p <0.001). AF after beating hear
t surgery is associated with a higher in-hospital morbidity, mortality, and
prolonged hospital stay. A minimally invasive surgical approach (minimally
invasive direct CABG) is associated with a lower risk of AF. (C) 2000 by E
xcerpta Medica, Inc.