Dose and duration of fenfluramine-phentermine therapy impacts the risk of significant valvular heart disease

Authors
Lepor, NE Gross, SB Daley, WL Samuels, BA Rizzo, MJ Luko, SP Hickey, A Buchbinder, NA Naqvi, TZ
Citation
Ne. Lepor et al., Dose and duration of fenfluramine-phentermine therapy impacts the risk of significant valvular heart disease, AM J CARD, 86(1), 2000, pp. 107
Citations number
19
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
Journal title
AMERICAN JOURNAL OF CARDIOLOGY
ISSN journal
00029149 → ACNP
Volume
86
Issue
1
Year of publication
2000
Database
ISI
SICI code
0002-9149(20000701)86:1<107:DADOFT>2.0.ZU;2-B
Abstract
Among a cohort of patients exposed to the anorexic combination fenfluramine -phentermine, a 30.6% rate of significant valvular regurgitation was found, predominantly affecting the aortic valve. Both the dose of combination the rapy and longer duration of use were significant predictors of valve regurg itation.