Long-term results and multivariate analysis of prognostic factors in 138 consecutive patients operated on for Crohn's disease using "bowel-sparing" techniques

BACKGROUND: Conservative surgery has become accepted as a useful option for the surgical treatment of complicated Crohn's disease (CD). METHODS: One hundred thirty-eight consecutive patients treated with strictu replasty or miniresections for complicated CD have been observed prospectiv ely. The possible influence of a number of variables on the risk of recurre nce was investigated using the Cox proportional hazard model, and a time-to -event analysis was made using the Kaplan-Meier function. RESULTS: There was no perioperative mortality; the morbidity rate was 5.7%. A close correlation was found between the risk of recurrence and the time between diagnosis and first surgery. The overall 5-year recurrence rate was 24%, being 36% in the patients requiring surgery within 1 year of diagnosi s and 14% in those operated on more than 1 year after diagnosis. CONCLUSIONS: Risk factor analysis highlighted a group of patients at high r isk of surgical recurrence. Given that our results are similar to those rep orted in other series, we consider stricture-plasty and miniresections safe and effective procedures for the treatment of complicated CD. Am J Surg. 2 000;179:266-270. (C) 2000 by Excerpta Medica, Inc.