Synthesis and biological activity of conformationally controlled 2-PAM derivatives

Authors
Jahng, Y Park, JG Yoo, JW Kim, SY Kim, T Yang, JH
Citation
Y. Jahng et al., Synthesis and biological activity of conformationally controlled 2-PAM derivatives, ARCH PH RES, 23(3), 2000, pp. 222-225
Citations number
15
Categorie Soggetti
Pharmacology & Toxicology
Journal title
ARCHIVES OF PHARMACAL RESEARCH
ISSN journal
02536269 → ACNP
Volume
23
Issue
3
Year of publication
2000
Pages
222 - 225
Database
ISI
SICI code
0253-6269(200006)23:3<222:SABAOC>2.0.ZU;2-J
Abstract
A series of conformationally controlled 2-PAM derivatives were prepared fro m 2-acetylpyridine and 2,3-pyrido[b]cycloalkenones in two steps and their r eactivities towards parathion poisoned AChE were evaluated. The most planar 2,3-pyrido[b]cyclohexanone oxime methiodide showed an activity comparable to 2-PAM implying E-syn is that the most active comformation of 2-PAM in th e biological system.