Multicomponent synthesis of novel amino acid-nucleobase chimeras: a versatile approach to PNA-monomers

This paper describes a multicomponent approach to novel totally protected p recursors of PNA-monomers via Ugi 4CC. The obtained bisamides are converted into several partially protected PNA-monomers or derivatives thereof using three different procedures. Methods for hydrolysis are shown to be depende nt on the nature of the isocyano component required for Ugi 4CC. Several no vel monomers suitable for oligomer synthesis are prepared demonstrating the high versatility of the reaction sequence. (C) 2000 Elsevier Science Ltd. All rights reserved.