Chemical modification of hyaluronidase as a means to regulate its inhibition by heparin

The modification of hyaluronidase by aldehydodextran regulates inhibition o f the enzyme by heparin. A 70-90% modification of the surface amino groups of hyaluronidase results in sharp conformational changes and a substantial decrease of its inhibition by heparin, whereas hyaluronidase derivatives wi th a modification degree of 96-100% are practically uninhibited.