The lack of the CpNpG methylation at the 5 '-terminal region of the human calcitonin gene in norm and leukemias

Authors
Buryanov, YI Shevchuk, TV Zakharchenko, NS D'yachenko, OV Marinich, DV Vorob'ev, IA
Citation
Yi. Buryanov et al., The lack of the CpNpG methylation at the 5 '-terminal region of the human calcitonin gene in norm and leukemias, BIOORG KHIM, 26(5), 2000, pp. 397-399
Citations number
13
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANICHESKAYA KHIMIYA
ISSN journal
01323423 → ACNP
Volume
26
Issue
5
Year of publication
2000
Pages
397 - 399
Database
ISI
SICI code
0132-3423(200005)26:5<397:TLOTCM>2.0.ZU;2-C
Abstract
The inner cytosine methylation was analyzed in the CCWGG sequences of the 5 '-terminal region of the human calcitonin gene from peripheral blood and bo ne marrow cells in various forms of leukemia. Since these sequences remain nonmethylated both in norm and in various leukemia forms, the CpG dinucleot ide hypermethylation of the 5'-terminus of the human calcitonin gene, chara cteristic for the development of leukemias, does not spread over adjacent C pNpG sequences.