Application of the Van Nuys prognostic index in a retrospective series of 367 ductal carcinomas in situ of the breast examinated by serial macroscopic sectioning: Practical considerations

The Van Nuys prognostic index (VNPI) was thought to be useful for predictin g response to radiotherapy and local recurrence of ductal carcinoma in situ (DCIS). We applied the VNPI under the conditions defined by Silverstein et al., in 367 retrospective DCIS entirely sectioned into serial macroscopic 2 mm slices (155 patients had radiotherapy, median follow-up 71 months). Th e percentage of positive blocks with DCIS was also estimated for each speci men with cut-offs at 30% and 60% to obtain three scores. One hundred and ni nety five lesions had a low VNPI, 152 an intermediate VNPI, and 20 a high V NPI. There were 9% of local recurrences (half invasive, all in the group wi thout radiotherapy) in the low VNPI group. The local recurrence rate increa sed with size (p=0.001), with reduction of distance to margins (p=0.05), wi th histologic grade (p=0.02), with percentage of positive blocks (p=0.0003) and with VNPI score (p=0.03). The percentage of positive blocks was the on ly independent predictor for local recurrence (p=0.0001). Conclusion: (1) The VNPI was a local recurrence rate predictor between the low and the intermediate groups but in our series the low VNPI group had a surprisingly high local recurrence rate. (2) Only prospective studies will assess the importance of margin width and the role of radiotherapy in maint aining local control. (3) Estimation of the percentage of positive blocks i s simple, may be an alternative when measurement of DCIS is difficult and s hould be taken into account.