Comparative QSAR evidence for a free-radical mechanism of phenol-induced toxicity

Citation
C. Hansch et al., Comparative QSAR evidence for a free-radical mechanism of phenol-induced toxicity, CHEM-BIO IN, 127(1), 2000, pp. 61-72
Citations number
29
Categorie Soggetti
Pharmacology & Toxicology
Journal title
CHEMICO-BIOLOGICAL INTERACTIONS
ISSN journal
00092797 → ACNP
Volume
127
Issue
1
Year of publication
2000
Pages
61 - 72
Database
ISI
SICI code
0009-2797(20000615)127:1<61:CQEFAF>2.0.ZU;2-W
Abstract
Phenol and 14 substituted-phenols were tested for their ability to impair e pithelial cell membrane integrity in WE rat liver cells as determined by an increase in lactate dehydrogenase release. Two quantitative structure-acti vity relationship (QSAR) regression equations were developed which showed t hat separate mechanisms of phenolic cytotoxicity are important - nonspecifi c toxicity due to hydrophobicity and formation of phenoxyl radicals. The eq uations most predictive of phenol toxicity are denoted as log 1/C = -0.98 s igma(+) + 0.77 log P + 0.23 or log 1/C = - 0.11BDE + 0.76 log P + 0.21, res pectively, where C is the minimum concentration of substituted-phenol requi red for a toxic response. P is the octanol water partition coefficient, sig ma(+) is the electronic Hammett parameter and BDE is the OH homolytic bond dissociation energy. In the literature, phenol toxicity correlated to sigma (+) is rare, but there is strong evidence that phenols possessing electron- releasing groups may be converted to toxic phenoxyl radicals. A common feat ure in a variety of cells is generation of elevated amounts of reactive oxy gen species (ROS) associated with a rapid growth rate. The slightly elevate d cancer risk associated with the use of Premarin may be due to phenoxyl-ty pe radicals derived from one or more of its components. (C) 2000 Elsevier S cience Ireland Ltd. All rights reserved.