Temporal lobe focal cortical dysplasia: MRI imaging using FLAIR shows lesions consistent with neoplasia

Focal cortical dysplasia (FCD), a form of neuronal migration disorder, is a malformative lesion of the neocortex that occurs during development of the brain. It can cause partial and generalized epilepsy. Seizures occur at an early age and are often resistant to medication. Surgical resection has be en found to be beneficial in these patients. Dual pa thology, in the form o f mesial temporal sclerosis, has been associated with FCD. At the Children' s Hospital of Eastern Ontario, four patients with temporal lobe FCD have re cently, been identified. This paper discusses how these children presented and how they were managed, with particular emphasis on their MRI findings a nd differential diagnoses. In three of the four patients neuroimaging studi es showed lesions consistent with a neoplastic process because of the large volume and mass effect. Radiologically, FCD may mimic the MRI appearance o f tumors, such as dysembryoplastic neuroepithelial tumors, primitive neuroe ctodermal tumors, gangliogliomas, oligodendrogliomas, and astrocytomas. The se lesions are best visualized on fluid-attenuated inversion recovery (FLAI R) imaging, a technique that has recently become applicable in the clinical setting, as we help demonstrate in this series. With better MRI capability , milder forms of FCD and microdysplasia may be distinguished.