Some geographical features of the location and gene mutation of cancers occurring in Nantong City, China

Objective To detect the location and geographical features of gene mutation of the cancer based on 30 709 clinical tumor biopsies. Methods Thirty thousand seven hundred and nine cases of tumor biopsy materi als were collected from the Department of Pathology of Nantong Cancer Hospi tal between June 1974 and December 1987. The address of the village and cou nty of patients was collected and statistical analysis was performed on dat a from lab examination. DNA sequencing of 31 cases of hepatocellular carcin oma (HCC) was performed at the Department of Pathology of the Medical Colle ge of Tokyo University, Japan. Results The data suggested that different carcinomas occurred predominantly in some districts and the frequency and type of mutation of the P53 gene i n the HCC were different in different districts. Conclusion It seems that based on the clinical biopsy materials, carcinomas of the uterus cervix (CC) and nasopharynx tend to occur in some districts of Nantong City and the frequency and type of mutation of the gene P53 of t he HCC were different in different districts. The reason for this is not un derstood and further study will be done.