The Global Initiative on Asthma (GINA) has provided guidelines for the mana
gement of children with asthma. For a step-wise approach to therapy, asthma
is divided into four categories based on severity of symptoms: intermitten
t, mild persistent, moderate persistent, and severe persistent asthma. Long
-term preventive therapy is distinguished from quick relief therapy in each
group. Although these guidelines are clear and simple there have been few
studies on asthma therapy for infants. Moreover, the existence of different
wheezing phenotypes with varying pathogenic mechanisms hampers the interpr
etation of these studies. Transient wheezers have stopped wheezing by the a
ge of 3 years and there is no relationship to atopy or a family history of
asthma. Tn contrast, persistent wheezers continue to wheeze from the first
year of life throughout school-age and have a high risk of atopy. Although
they have normal lung function at birth, persistent wheezers develop signif
icant decrements in lung function by the age of 6 years. Whether these impa
irments are amenable to prevention by early initiation of antiinflammatory
therapy remains to be seen. At present, there are no disease markers to ide
ntify the different wheezing phenotypes in infancy, although eosinophil cou
nts and measurements of eosinophil cationic protein in serum may prove to b
e helpful in distinguishing these conditions.