Dysmenorrhoea - Clinical evidence with piroxicam-beta-cyclodextrin

Primary dysmenorrhoea can be readily relieved with nonsteroidal anti-inflam matory drugs (NSAIDs). These drugs inhibit prostaglandin synthetase, reduci ng the level of prostanoids in the uterus and the uterine contractions that cause the painful cramps. Piroxicam-beta-cyclodextrin is rapidly absorbed and quickly reaches peak blood concentrations. Four published clinical stud ies have evaluated piroxicam-beta-cyclodextrin for relief of primary dysmen orrhoea. Piroxicam-beta-cyclodextrin 20mg once daily was significantly more effective than placebo in relief of dysmenorrhoea, was better than ketopro fen in relieving the abdominal pain of dysmenorrhoea, and had a quicker ons et and longer duration of relief than naproxen. Both investigators and pati ents rated a greater preference for piroxicam-beta-cyclodextrin over the co mparator medications. The tolerability of piroxicam-beta-cydodextrin in the treatment of dysmenorrhoea was good, with a very low incidence of adverse effects.