Vasopressin and A1 noradrenaline turnover during food or water deprivationin the rat

Citation
S. El Fazaa et al., Vasopressin and A1 noradrenaline turnover during food or water deprivationin the rat, COMP BIOC C, 126(2), 2000, pp. 129-137
Citations number
39
Categorie Soggetti
Pharmacology & Toxicology
Journal title
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY
ISSN journal
13678280 → ACNP
Volume
126
Issue
2
Year of publication
2000
Pages
129 - 137
Database
ISI
SICI code
1367-8280(200006)126:2<129:VAANTD>2.0.ZU;2-M
Abstract
In the present study, we have examined in Wistar rats the effects of food o r water deprivation of 3 days on the hypophyso-adrenal axis, vasopressinerg ic system and activity of Al noradrenergic brain stem cell group, which is involved in the control of the hypothalamic neuro-endocrine activity. Level s of adrenocorticotropic hormone (ACTH) and vasopressin (AVP) were determin ed by radio-immunoassay, and corticosterone level was determined by fluorim etric method. Plasma levels of ACTH and corticosterone were greatly increas ed in both groups of rats. In water-deprived rats: plasma AVP (13.83 +/- 1. 63 vs. 3.03 +/- 0.23 pg/ml) and osmolality levels were significantly elevat ed with a marked decrease of AVP hypophysis content (272 +/- 65 vs. 1098 +/ - 75 ng/mg protein), but not in food-deprived rats in which osmolality did not change and AVP remained stocked (2082 +/- 216 ng/mg protein) in the hyp ophysis without release in the plasma (1.11+/-0.23 pg/ml). These observatio ns indicated that both food-deprivation and water-deprivation stimulated th e pituitary-adrenal axis thereby suggesting a stress state. AVP production is stimulated both by fluid and food restriction but is secreted with diffe rential effects: during food restriction AVP secretion is limited to suppor ting the hypothalamic-pituitary-adrenal system. (C) 2000 Elsevier Science I nc. All rights reserved.