Lactic acid bacteria as a cell factory: rerouting of carbon metabolism in Lactococcus lactis by metabolic engineering

Authors
Kleerebezem, M Hols, P Hugenholtz, J
Citation
M. Kleerebezem et al., Lactic acid bacteria as a cell factory: rerouting of carbon metabolism in Lactococcus lactis by metabolic engineering, ENZYME MICR, 26(9-10), 2000, pp. 840-848
Citations number
53
Categorie Soggetti
Biotecnology & Applied Microbiology",Microbiology
Journal title
ENZYME AND MICROBIAL TECHNOLOGY
ISSN journal
01410229 → ACNP
Volume
26
Issue
9-10
Year of publication
2000
Pages
840 - 848
Database
ISI
SICI code
0141-0229(200006)26:9-10<840:LABAAC>2.0.ZU;2-J
Abstract
Lactic acid bacteria display a relatively simple metabolism wherein the sug ar is converted mainly to lactic acid. The extensive knowledge of metabolic pathways and the increasing information of the genes involved allows For t he rerouting of natural metabolic pathways by genetic and physiological eng ineering. We discuss several examples of metabolic engineering of Lactococc us lactis for the production of important compounds, including diacetyl, al anine and exopolysaccharides, (C) 2000 Elsevier Science Inc. All rights res erved.