Randomized trial of two local antiseptics in bacterial vaginal infections

Objective: In a phase 3 clinical trial we compared the efficacy and side ef fects of a new local antiseptic solution (Octeniphen(R)) with that of povid one-iodine vaginal suppositories for the treatment of bacterial vaginal inf ections (bacterial colpitis, bacterial fluor vaginalis, bacterial vaginosis ). Methods: A total of 308 patients were enrolled and randomly assigned to rec eive 7 days of local therapy with one of the two agents. Patients were reex amined clinically and microscopically at 7 days. Results: Improvement of symptoms was more frequent in patients using Octeni phen(R) than in those using povidine-iodine (75% vs. 65%, respectively; t = 1.89). Restitution of lactobacilli was significantly more common (46% vs. 29%, t = 2.76) and patient compliance better with Octeniphen(R). No changes in cytomorphology or proliferation of the vaginal epithelium was seen in e ither group. Both agents were well tolerated. Conclusion: Octeniphen(R) appears to be effective and well tolerated for th e treatment of bacterial vaginal infections.