Background: Studies of extraocular muscle (EOM) by magnetic resonance imagi
ng (MRI) need to be extended to normal subjects of different ages to obtain
data on the muscle thickness, cross-sectional area, and the volume of EOM
and other orbital tissues. Methods: Forty-two orbits of 21 normal subjects
in three age groups with an age range of 19-70 years were examined with sur
face-coil MRT. The transverse and sagittal images were used to measure the
thickness of the four rectus muscles during fixation in different gaze posi
tions. The coronal images with eyes in the primary position were used to ca
lculate the cross-sectional areas. The volumes of all six EOM, orbital fatt
y tissue, the optic nerve and the eyeball were measured in the coronal plan
e and in either the transverse or the sagittal plane. Results: The horizont
al muscles were thinner than vertical muscles. Muscle volume was larger in
SR (superior rectus) than in IR (inferior rectus), larger in SO (superior o
blique) than in IO (inferior oblique), and the same in LR (lateral rectus)
as in MR (medial rectus). No significant differences were found in the valu
es of the cross-sectional area in any image plane between the three age gro
ups. There were no significant differences in muscle thickness and size and
fatty tissue volume between age groups. The muscle thickness was linearly
correlated to the angle of the eye deviation for all four rectus muscles, b
oth in the "on" and "off" directions of the muscles. Conclusions: The study
provides quantitative data, in normal subjects of different ages, on the t
hickness and size of EOM and the volume of other orbital tissues by MRI, to
serve as a basis for further studies on the morphological changes of EOM i
n various orbital diseases.