Glomosporin, a novel antifungal cyclic depsipeptide from Glomospora sp. I.Production, isolation, physico-chemical properties and biological activities

Authors
Sato, T Ishiyama, D Honda, R Senda, H Konno, H Tokumasu, S Kanazawa, S
Citation
T. Sato et al., Glomosporin, a novel antifungal cyclic depsipeptide from Glomospora sp. I.Production, isolation, physico-chemical properties and biological activities, J ANTIBIOT, 53(6), 2000, pp. 597-602
Citations number
7
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF ANTIBIOTICS
ISSN journal
00218820 → ACNP
Volume
53
Issue
6
Year of publication
2000
Pages
597 - 602
Database
ISI
SICI code
0021-8820(200006)53:6<597:GANACD>2.0.ZU;2-B
Abstract
A novel antifungal cyclic depsipeptide termed glomosporin, which has a fatt y acyl side chain, was isolated from a barley solid culture of Glomospora s p. The strain was isolated from fallen pine leaves collected in Fukusima Pr efecture, Japan and identified as Glomospora sp. BAUA 2825. Glomosporin was purified by butanol extraction followed by preparative HPLC . Glomosporin showed antimicrobial activity against fungi including clinica lly important Aspergillus fumigatus.