Background/Aim: Serum levels of leptin, the adipocyte-derived hormone regul
ating food intake and energy expenditure in mammals, have been found to be
increased in cirrhotic patients. The aim of the present study was to invest
igate leptin serum level in relation to anthropometric features and liver f
unction in patients with viral chronic hepatitis or liver cirrhosis.
Methods: Serum leptin levels were determined by radioimmunoassay in 30 male
and 10 female patients with chronic hepatitis, in 42 male and 10 female pa
tients with liver cirrhosis, and in four respective control groups. Liver f
unction was evaluated by the monoethylglycinexylidide formation test. Body
mass index and body fat mass were estimated by weight, height and skinfold
thickness measurements.
Results: Compared with controls, absolute serum leptin levels were signific
antly (p<0.01) lower in chronic hepatitis patients and similar in cirrhotic
patients. Leptin serum levels were significantly (p<0.05) higher in cirrho
tic than in chronic hepatitis patients. When expressed in relation to body
fat mass, the above differences persisted; however, cirrhotic females showe
d significantly (p<0.05) higher serum leptin values than controls. Serum le
ptin values correlated negatively (p<0.01) with monoethylglycinexylidide se
rum values in all groups of patients.
Conclusions: In patients with chronic viral liver disease, serum leptin lev
els tend to increase as liver function worsens. This may reflect a decline
in the ability to downregulate energy expenditure as an adaptation to anore
xia and/or to defective substrate utilisation due to liver disease and may
negatively influence body weight homeostasis in these patients.