Recurrent cholestatic jaundice associated with generalized pustular psoriasis: evidence for a neutrophilic cholangitis

Generalized pustular psoriasis can result in systemic complications. We rep ort the case of a woman with relapsing generalized pustular psoriasis and r ecurring episodes of cholestatic jaundice. Liver biopsy performed during an attack showed a neutrophilic infiltrate surrounding and invading portal tr iad bile ducts. Ultrasonographic exams and retrograde cholangiography ruled out biliary tract disease. This observation suggests that recurring choles tatic jaundice in pustular psoriasis is related to a neutrophilic cholangit is.