Effects of somatostatin analogues and vitamin C on bacterial translocationin an experimental intestinal obstruction model of rats

The passage of viable endogenous bacteria and their products across the int act intestinal mucosal barrier, disseminating to the mesenteric lymph nodes , peritoneal cavity, spleen, liver, and circulation, is defined as bacteria l translocation. Intestinal obstruction induces bacterial translocation due to mucosal disruption, motility dysfunction, and increased intestinal volu me, leading to bacterial overgrowth. In a rat model of intestinal obstructi on, the effects of both high-dose vitamin C (350 mu g/kg), an antioxidant a gent known to have a cytoprotective effect in ischemia-reperfusion injury, and somatostatin (20 mu g/kg), a gastrointestinal antisecretory agent, in p reventing bacterial translocation were studied. Both intestinal and liver s amples from the rats was observed, and it was found that the rate of bacter ial translocation was 100% in the control group, and only 43% for the rats who were given intraperitoneal vitamin C and somatostatin. The difference w as statistically significant. In conclusion, we are convinced that vitamin C and somatostatin analogues may have protective effects against bacterial translocation in mechanical bowel obstruction.