Laryngeal leiomyosarcoma

We report one case of leiomyosarcoma (LMS) of the larynx occurring in a pat ient with a history of immunosuppressive therapy, and offer a critical revi ew of the literature. Epstein-Barr virus (EBV) genome was not identified in the neoplastic cells. The patient was treated with endoscopic resection an d post-operative radiotherapy. Lung metastasis and thyroid infiltration bec ame evident 14 months following treatment despite the absence of laryngeal recurrence. Progressive decline occurred and the patient died 15 months aft er diagnosis.