Model reduction by extended quasi-steady-state approximation

Citation
Kr. Schneider et T. Wilhelm, Model reduction by extended quasi-steady-state approximation, J MATH BIOL, 40(5), 2000, pp. 443-450
Citations number
24
Categorie Soggetti
Multidisciplinary
Journal title
JOURNAL OF MATHEMATICAL BIOLOGY
ISSN journal
03036812 → ACNP
Volume
40
Issue
5
Year of publication
2000
Pages
443 - 450
Database
ISI
SICI code
0303-6812(200005)40:5<443:MRBEQA>2.0.ZU;2-A
Abstract
We extend the quasi-steady-state approximation (QSSA) with respect to the c lass of differential systems as well as with respect to the order of approx imation. We illustrate the first extension by an example which cannot be tr eated in the frame of the classical approach. As an application of the seco nd extension we prove that the trimolecular autocatalator can be approximat ed by a fast bimolecular reaction system. Finally we describe a class of si ngularly perturbed systems for which a higher order QSSA can easily be obta ined.