A three-dimensional serpentine microchannel design with a "C-shaped" repeat
ing unit is presented in this paper as a means of implementing chaotic adve
ction to passively enhance fluid mixing, The device is fabricated in a sili
con wafer using a double-sided KOH wet-etching technique to realize a three
-dimensional channel geometry. Experiments using phenolphthalein and sodium
hydroxide solutions demonstrate the ability of flow in this channel to mix
faster and more uniformly than either pure molecular diffusion or flow in
a "square-wave" channel for Reynolds numbers from 6 to 70, The mixing capab
ility of the channel increases with increasing Reynolds number. At Least 98
% of the maximum intensity of reacted phenolphthalein is observed in the ch
annel after five mixing segments for Reynolds numbers greater than 25, At a
Reynolds number of 70, the serpentine channel produces 16 times more react
ed phenolphthalein than a straight channel and 1.6 times more than the squa
re-wave channel. Mixing rates in the serpentine channel at the higher Reyno
lds numbers are consistent with the occurrence of chaotic advection. Visual
ization of the interface formed in the channel between streams of water and
ethyl alcohol indicates that the mixing is due to both diffusion and fluid
stirring.