Regression of a presumed meningioma with the antiestrogen agent mepitiostane - Case report

This 68-year-old woman underwent a distal gastrectomy for gastric cancer in August 1994. A presumed meningioma of the fair was found incidentally on a staging examination of the gastric cancer, but the meningioma was not trea ted with surgery. Instead, after gastrectomy the patient received tegafur a s adjuvant chemotherapy until February 1996, when she was readmitted to the hospital because of loss of appetite and emaciation but with no recurrence of the gastric cancer. A computerized tomography scan obtained during this second admission showed no change in the meningioma. To improve her genera l condition, tegafur was discontinued and she was started on a course of th e antiestrogen agent mepitiostane. Administration of mepitiostane for appro ximately 2 years resulted in a marked regression (73%) of the meningioma. T his is the first reported case of a presumed meningioma that regressed as a result of use of the antiestrogen agent mepitiostane.