Study of beta-blockers/beta-cyclodextrins inclusion complex by NMR, DSC, X-ray and SEM investigation

The formation of inclusion complexes between beta-cyclodextrin with the two beta-blockers, atenolol and celiprolol, have been studied in the aqueous e nvironment and in the solid state by nuclear magnetic resonance (NMR) spect roscopy, X-ray, differential scanning calorimetry (DSC) and scanning electr on microscopy (SEM) techniques. The magnitude of the chemical shirts of the interior and exterior beta-cyclodextrin protons in the presence of each be ta-blocker indicated that these are included within the beta-cyclodextrin c avity. In aqueous solution they form 1:1 complexes. In the solid state the formation of the beta-cyclodextrin/atenolol (celiprolol) complexes is confi rmed by X-ray, DSC and SEM, also employed to characterize pure substances a nd their physical mixtures. (C) 2000 Elsevier Science B.V. All rights reser ved.