Simultaneous determination of losartan and hydrochlorothiazide in tablets by high-performance liquid chromatography

Authors
Carlucci, G Palumbo, G Mazzeo, P Quaglia, MG
Citation
G. Carlucci et al., Simultaneous determination of losartan and hydrochlorothiazide in tablets by high-performance liquid chromatography, J PHARM B, 23(1), 2000, pp. 185-189
Citations number
32
Categorie Soggetti
Chemistry & Analysis
Journal title
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
ISSN journal
07317085 → ACNP
Volume
23
Issue
1
Year of publication
2000
Pages
185 - 189
Database
ISI
SICI code
0731-7085(20000801)23:1<185:SDOLAH>2.0.ZU;2-0
Abstract
A method for the simultaneous determination of losartan potassium and hydro chlorothiazide in tablets is described. The procedure, based on the use of reversed-phase high-performance liquid chromatography, is linear in the con centration lange 3.0-7.0 mu g ml(-1) for losartan and 0.5-2.0 mu g ml(-1) f or hydrochlorothiazide, is simple and rapid and allows accurate and precise results. The limit of detection was 0.08 mu g ml(-1) for losartan and 0.05 mu g ml(-1) for hydrochlorothiazide. (C) 2000 Elsevier Science B.V. All ri ghts reserved.